Microfluidic lab-on-a-chip device with fluid channels on a glass substrate

Life Sciences

Glass for LOAC and Micro-Nano Sensors (EN-A1 / AQ Grade)

Industry-preferred glass substrates (EN-A1 and AQ-grade quartz) for Lab-on-a-Chip, DNA microreactors, micro-nano sensors, and handheld diagnostic devices.

EN-A1 and AQ-grade quartz are the industry’s preferred biosensor glass substrates for Lab-on-a-Chip (LOAC), microfluidics devices, DNA microreactors, micro-nano sensors, and handheld point-of-care diagnostic devices in life sciences. Each grade is optimized for a different point on the cost/performance curve, with engineered surfaces for the micro-channel structures that LOAC platforms depend on.

EN-A1: the high-volume workhorse

EN-A1 is a low-cost substrate for high-volume applications where signal-to-noise is not the dominant requirement.

  • Lowest-in-class fluorescing emission. Makes it the premier choice for 570 nm and 670 nm bio-markers used in DNA gene sequencing and expression studies.
  • Sodium-free. Works well with most chemistries; does not interfere with detection or cause premature polymerization.
  • Standard thicknesses of 0.3, 0.5, and 0.7 mm.
  • Standard polish of < 1 nm Ra. Roughness from 5 Å down to < 2 Å available for special applications.
  • Pre-drilled vias from 70 µm down to 30 µm, with or without copper fill.
  • Wafer sizes up to 300 mm.
  • Panel formats available to increase yield and lower manufacturing cost.
  • A variety of metallic coatings can be applied.

AQ quartz: the performance substrate

AQ quartz delivers the cleanest, lowest-autofluorescence surface for reactor microarrays and sequencing where absolute performance is required.

  • No detectable fluorescing emission in the priority frequency range for CY3 and CY5 bio-markers. The ultimate substrate for biological-marker applications.
  • Transparent down to 190 nm.
  • Low and controllable surface roughness.
  • Low electrical loss and exceptionally low RF tan δ for low-power sensors.
  • Wafer sizes up to 300 mm.
  • Pre-drilled vias from 70 µm down to 30 µm, with or without copper fill.
  • A variety of metallic coatings can be applied.

Selecting between them

For high-volume diagnostic devices where cost dominates, EN-A1 typically gives the right balance of optical performance and manufacturability. For research, sequencing, and high-precision sensors where absolute fluorescence performance or sub-200 nm transmission matters, AQ is the substrate to specify.

Applications

  • Lab-on-a-Chip (LOAC) devices
  • DNA microreactors and gene-sequencing microarrays
  • Micro-nano sensors and biosensors
  • Handheld diagnostic devices

Documents

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Specifications

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